Targeting oxidative pentose phosphate pathway prevents recurrence in mutant Kras colorectal carcinomas.
Recurrent tumors originate from cancer stem cells (CSCs) that survive conventional treatments.CSCs consist of heterogeneous subpopulations that display distinct sensitivity to anticancer drugs.Such a heterogeneity presents a significant challenge in preventing tumor recurrence.In the current study, we observed that quiescent CUB-domain-containing p